Weak bases display better: kinetic deprotonative functionalization

The C–H bond deprotonation and functionalization reaction represents the most frequently used method for C–C construction also a vital mode of activation. Great developments have been made recently in catalytic formation by using weakly acidic compounds as nucleophiles. The strongly basic reagent or catalyst is key factor these reactions. If only base enough, bonds, carbanions following nucleophilic reactions occur according to acid-base equilibrium theory. Even though relative weak not strong enough deprotonation, carbanion still exists system, possibly very low concentration. Once selectively undergoes thermodynamically favoured transformation, its concentration goes down thus starts reestablishment equilibrium. With combination irreversible conversion constant equilibrium, deprotonative bonds could be achieved slowly but continuously under conditions. Distinct from conventional via intermediate, we suggest descriptive name “kinetic functionalization” conditions Herein, will briefly review research status discuss kinetic developed our group.